HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Identifieur interne : 003866 ( Main/Exploration ); précédent : 003865; suivant : 003867HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Auteurs : Fatiha Tabet [Australie] ; Kasey C. Vickers [États-Unis] ; Luisa F. Cuesta Torres [Australie] ; Carrie B. Wiese [États-Unis] ; Bassem M. Shoucri [États-Unis] ; Gilles Lambert [France] ; Claire Catherinet [Australie] ; Leonel Prado-Lourenco [Australie] ; Michael G. Levin [États-Unis] ; Seth Thacker [États-Unis] ; Praveen Sethupathy [États-Unis] ; Philip J. Barter [Australie] ; Alan T. Remaley [États-Unis] ; Kerry-Anne Rye [Australie]Source :
- Nature communications [ 2041-1723 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Cellules endothéliales (métabolisme), Cellules endothéliales de la veine ombilicale humaine, Expression des gènes, Femelle, Humains, Lipoprotéines HDL (métabolisme), Molécule-1 d'adhérence intercellulaire (métabolisme), Mâle, Régulation de l'expression des gènes, Souris de lignée C57BL, Vaisseaux coronaires (cytologie), Vaisseaux coronaires (métabolisme), Volontaires sains, microARN (métabolisme).
- MESH :
- cytologie : Vaisseaux coronaires.
- métabolisme : Cellules endothéliales, Lipoprotéines HDL, Molécule-1 d'adhérence intercellulaire, Vaisseaux coronaires, microARN.
- Adulte, Animaux, Cellules endothéliales de la veine ombilicale humaine, Expression des gènes, Femelle, Humains, Mâle, Régulation de l'expression des gènes, Souris de lignée C57BL, Volontaires sains.
English descriptors
- KwdEn :
- Adult, Animals, Coronary Vessels (cytology), Coronary Vessels (metabolism), Endothelial Cells (metabolism), Female, Gene Expression, Gene Expression Regulation, Healthy Volunteers, Human Umbilical Vein Endothelial Cells, Humans, Intercellular Adhesion Molecule-1 (metabolism), Lipoproteins, HDL (metabolism), Male, Mice, Inbred C57BL, MicroRNAs (metabolism).
- MESH :
- chemical , metabolism : Intercellular Adhesion Molecule-1, Lipoproteins, HDL, MicroRNAs.
- cytology : Coronary Vessels.
- metabolism : Coronary Vessels, Endothelial Cells.
- Adult, Animals, Female, Gene Expression, Gene Expression Regulation, Healthy Volunteers, Human Umbilical Vein Endothelial Cells, Humans, Male, Mice, Inbred C57BL.
Abstract
High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppresses expression of intercellular adhesion molecule 1 (ICAM-1) through the transfer of miR-223 to endothelial cells. After incubation of endothelial cells with HDL, mature miR-223 levels are significantly increased in endothelial cells and decreased on HDL. However, miR-223 is not transcribed in endothelial cells and is not increased in cells treated with HDL from
Url:
DOI: 10.1038/ncomms4292
PubMed: 24576947
PubMed Central: 4189962
Affiliations:
- Australie, France, États-Unis
- Nouvelle-Galles du Sud, Pays de la Loire
- Nantes, Sydney
- Université de Nantes, Université de Sydney
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Le document en format XML
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</author>
<author><name sortKey="Thacker, Seth" sort="Thacker, Seth" uniqKey="Thacker S" first="Seth" last="Thacker">Seth Thacker</name>
<affiliation wicri:level="1"><nlm:aff id="A4">National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20814-9692, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20814-9692</wicri:regionArea>
<wicri:noRegion>Maryland 20814-9692</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sethupathy, Praveen" sort="Sethupathy, Praveen" uniqKey="Sethupathy P" first="Praveen" last="Sethupathy">Praveen Sethupathy</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264</wicri:regionArea>
<wicri:noRegion>North Carolina 27599-7264</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Centre for Vascular Research, The University of New South Wales, Sydney, New South Wales 2052, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vascular Research, The University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea>
<wicri:noRegion>New South Wales 2052</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Lipid Research Group, The Heart Research Institute, New South Wales 2042, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lipid Research Group, The Heart Research Institute, New South Wales 2042</wicri:regionArea>
<wicri:noRegion>New South Wales 2042</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, Sydney New South Wales 2006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Medicine, University of Sydney, Sydney New South Wales 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T." last="Remaley">Alan T. Remaley</name>
<affiliation wicri:level="1"><nlm:aff id="A4">National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20814-9692, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20814-9692</wicri:regionArea>
<wicri:noRegion>Maryland 20814-9692</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Centre for Vascular Research, The University of New South Wales, Sydney, New South Wales 2052, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vascular Research, The University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea>
<wicri:noRegion>New South Wales 2052</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Lipid Research Group, The Heart Research Institute, New South Wales 2042, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lipid Research Group, The Heart Research Institute, New South Wales 2042</wicri:regionArea>
<wicri:noRegion>New South Wales 2042</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, Sydney New South Wales 2006, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Medicine, University of Sydney, Sydney New South Wales 2006</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Coronary Vessels (cytology)</term>
<term>Coronary Vessels (metabolism)</term>
<term>Endothelial Cells (metabolism)</term>
<term>Female</term>
<term>Gene Expression</term>
<term>Gene Expression Regulation</term>
<term>Healthy Volunteers</term>
<term>Human Umbilical Vein Endothelial Cells</term>
<term>Humans</term>
<term>Intercellular Adhesion Molecule-1 (metabolism)</term>
<term>Lipoproteins, HDL (metabolism)</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>MicroRNAs (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Cellules endothéliales (métabolisme)</term>
<term>Cellules endothéliales de la veine ombilicale humaine</term>
<term>Expression des gènes</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lipoprotéines HDL (métabolisme)</term>
<term>Molécule-1 d'adhérence intercellulaire (métabolisme)</term>
<term>Mâle</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
<term>Vaisseaux coronaires (cytologie)</term>
<term>Vaisseaux coronaires (métabolisme)</term>
<term>Volontaires sains</term>
<term>microARN (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intercellular Adhesion Molecule-1</term>
<term>Lipoproteins, HDL</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Vaisseaux coronaires</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Coronary Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronary Vessels</term>
<term>Endothelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term>
<term>Lipoprotéines HDL</term>
<term>Molécule-1 d'adhérence intercellulaire</term>
<term>Vaisseaux coronaires</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Animals</term>
<term>Female</term>
<term>Gene Expression</term>
<term>Gene Expression Regulation</term>
<term>Healthy Volunteers</term>
<term>Human Umbilical Vein Endothelial Cells</term>
<term>Humans</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Animaux</term>
<term>Cellules endothéliales de la veine ombilicale humaine</term>
<term>Expression des gènes</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
<term>Volontaires sains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliver functional microRNAs (miRNA). Here we show that HDL suppresses expression of intercellular adhesion molecule 1 (ICAM-1) through the transfer of miR-223 to endothelial cells. After incubation of endothelial cells with HDL, mature miR-223 levels are significantly increased in endothelial cells and decreased on HDL. However, miR-223 is not transcribed in endothelial cells and is not increased in cells treated with HDL from <italic>miR-223</italic>
<sup>−/−</sup>
mice. HDL inhibit ICAM-1 protein levels, but not in cells pretreated with miR-223 inhibitors. ICAM-1 is a direct target of HDL-transferred miR-223 and this is the first example of an extracellular miRNA regulating gene expression in cells where it is not transcribed. Collectively, we demonstrate that HDL’s anti-inflammatory properties are conferred, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>États-Unis</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Pays de la Loire</li>
</region>
<settlement><li>Nantes</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Nantes</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name>
</noRegion>
<name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
<name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
<name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name>
<name sortKey="Catherinet, Claire" sort="Catherinet, Claire" uniqKey="Catherinet C" first="Claire" last="Catherinet">Claire Catherinet</name>
<name sortKey="Cuesta Torres, Luisa F" sort="Cuesta Torres, Luisa F" uniqKey="Cuesta Torres L" first="Luisa F." last="Cuesta Torres">Luisa F. Cuesta Torres</name>
<name sortKey="Cuesta Torres, Luisa F" sort="Cuesta Torres, Luisa F" uniqKey="Cuesta Torres L" first="Luisa F." last="Cuesta Torres">Luisa F. Cuesta Torres</name>
<name sortKey="Prado Lourenco, Leonel" sort="Prado Lourenco, Leonel" uniqKey="Prado Lourenco L" first="Leonel" last="Prado-Lourenco">Leonel Prado-Lourenco</name>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name>
<name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name>
<name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Vickers, Kasey C" sort="Vickers, Kasey C" uniqKey="Vickers K" first="Kasey C." last="Vickers">Kasey C. Vickers</name>
</noRegion>
<name sortKey="Levin, Michael G" sort="Levin, Michael G" uniqKey="Levin M" first="Michael G." last="Levin">Michael G. Levin</name>
<name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T." last="Remaley">Alan T. Remaley</name>
<name sortKey="Sethupathy, Praveen" sort="Sethupathy, Praveen" uniqKey="Sethupathy P" first="Praveen" last="Sethupathy">Praveen Sethupathy</name>
<name sortKey="Shoucri, Bassem M" sort="Shoucri, Bassem M" uniqKey="Shoucri B" first="Bassem M." last="Shoucri">Bassem M. Shoucri</name>
<name sortKey="Thacker, Seth" sort="Thacker, Seth" uniqKey="Thacker S" first="Seth" last="Thacker">Seth Thacker</name>
<name sortKey="Vickers, Kasey C" sort="Vickers, Kasey C" uniqKey="Vickers K" first="Kasey C." last="Vickers">Kasey C. Vickers</name>
<name sortKey="Wiese, Carrie B" sort="Wiese, Carrie B" uniqKey="Wiese C" first="Carrie B." last="Wiese">Carrie B. Wiese</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name>
</region>
</country>
</tree>
</affiliations>
</record>
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